Occupation of ACE receptor by SARS-CoV-۲ and male infertility risk: An in silico analysis

Backgrounds: SARS-CoV-۲ has a single-stranded RNA-plus genome (~۳۰ kb) with five majoropen reading frames, which is encode nonstructural replicase polyproteins and structuralproteins: Spike (S), Envelope (E), Membrane (M), and Nucleocapsid (N). Spike protein asknown a causative ligand for mammalian cell’s angiotensin-converting enzyme ۲ (ACE۲)receptor which transmits the virus in to host cells. Due to the high expression of ACE and ACE۲receptor in various organs, the aim of this study is to investigation of correlation between ACEand ACE۲ receptor with other proteins, which involved in the male infertility using by in silicoanalysis.Materials and Methods: In this study free web databases such as NCBI(https://www.ncbi.nlm.nih.gov) and MalaCards (https://www.malacards.org) and online proteinsinteraction data analyzer e.g., GeneMANIA server (https://genemania.org) were used.Results: Our studies showed that ACE and ACE۲ receptors have a higher expression intesticular tissue. In other hand interaction between proteins showed these receptors have coexpressionwith Protamine ۱/PRM۱ and Protamine ۲/ PRM۲.Conclusion: Since Protamines are a special protein in the sperm cells, so defective of thisprotein cause the sperm abnormalities and affects in male infertility. We recommend, occupationof ACE and ACE۲ receptors by SARS-CoV-۲ may cause to verity of protamine expression level,which effect on male infertility risk.

کلیدواژه ها:

Angiotensin-converting enzyme (ACE) ، In silico analysis ، Male infertility ، Protamine ، SARS-CoV-۲