LC۳B as a novel marker for diagnosis of cancer

Background: Worldwide, cancer is the most common malignancy and the most commoncause of deaths in the past few decades. Early diagnosing of cancer by novel biomarkers is apublic and policy priority. A prognostic biomarker provides information on the likely outcome ofthe disease in an untreated individual and is helpful in identifying patients for adjuvant systemictherapies. Recently, autophagy genes and proteins have attracted the attention of manyresearchers as diagnostic biomarkers. One of them is the microtubule-associated protein ۱ lightchain ۳B (MAP۱LC۳B, or LC۳B), has long served as an autophagy marker in multiple in vitroassays. The expression levels of LC۳B gene and protein have also been examined by newmolecular methods and immunohistochemistry in many cancers. The results of recent studiesshowed that high gene and protein expression of LC۳B predicted adverse overall survival incancers. Thus these data suggest that LC۳B could be a clinically useful biomarker as a diagnosticand/or prognostic tool in cancer.Materials and Methods: The current review has been achieved by using an organized search ofthe scientific data published on molecular biology of LC۳B from various databases, includingPubMed, ScienceDirect, Scopus, Scielo, SciFinder and Google Scholar.Results: The results of the gene and present study showed LC۳B could be a good candidate as aprognostic factor to diagnosis of cancer.Conclusion: LC۳B has been reported to be a potential biomarker of cancers. Given the dire needfor tumor markers, only further studies can establish the utility of LC۳B in the detection andtreatment of cancer and provide irrefutable evidence for its diagnostic and/or prognostic use as anew weapon against human cancer.

کلیدواژه ها:

cancer ، autophagy ، LC۳B ، biomarker