Investigation of the Association of FOLH۱ rs۶۱۸۸۶۴۹۴ and DISC۱ rs۱۲۱۳۳۷۶۶ loci in Iranian Schizophrenia Patients

Background: The aim of this study was to identification of polymorphisms of FOLH۱ andDISC۱ genes in Iranian patients with schizophrenia.Materials and Methods: In this case-control study, ۵۰ patients with schizophrenia and ۵۰healthy controls were evaluated. PCR-RFLP and Tetra-ARMS methods were used for detectionof FOLH۱ and DISC۱ gene respectively in both of patients and control groups.Results: The frequency of CC, CT, and TT genotypes for FOLH۱ gene in rs۶۱۸۸۶۴۹۴ locus inschizophrenic patients was ۹۲%, ۸%, and ۰%, respectively, and in healthy subjects, ۹۴%, ۰%,and ۶%, respectively. The frequency of DISC gene in GG genotype was higher than that ofnormal people and frequency of GA genotype was lower than normal subjects. In addition, thegenotype AA was identified only in patients.Conclusion: For FOLH۱ gene in rs۶۱۸۸۶۴۹۴ locus, the frequency of CC and TT genotypes inpatients was ۲% and ۶% lower in healthy people, while CT genotype in patients was ۸% higherin healthy people. Interestingly, TT genotype was not observed in patients and CT genotype inhealthy people was not observed. Regarding the DISC۱ gene, the results showed that thefrequency of homozygous GG and GA homozygote genotypes in the patients was higher in thers۱۲۱۳۳۷۶۶ locus, while the heterozygote GA was high in healthy subjects and was not observedin patients. Therefore, the result of this study in our country can provide suitable method fordiagnosis and prevention of schizophrenia patients.

کلیدواژه ها:

Schizophrenia ، polymorphism ، DISC۱ gene ، FOLH۱ gene