Bioinformatics evaluation of hsa-miR-۲۰۵-۵p signaling pathways and related function of tp۵۳ in patients with pancreatic cancer

Background: Pancreatic cancer is among the deadliest cancers and more than ۳۳۱,۰۰۰ deaths ayear, making it the seventh leading cause of cancer death in both sexes combined. Pancreaticcancer develops when cells in the pancreas the glandular organ behind the stomach generatemultiply uncontrollably and form a mass. The Tp۵۳ gene is located on chromosome ۱۷, and it isa tumor suppressor gene that encodes a transcriptional activator protein that responds toapoptosis. The aim of this study was to find more bioinformatics information.Materials and Methods: General information about Tp۵۳ was obtained from NCBI database.The microRNA was chosen through miRwalk database. More data was achieved from miRbasedatabase, and DAVID made the acquire sortment of pathways connected to Tp۵۳ gene. Inaddition, KEGG showed carcinogene pathways associated with Tp۵۳ gene.Results: the bioinformatics prediction showed that the tumor suppressor role of the tp۵۳ gene isresponsible for the microRNA's binding location.Conclusion: Previous bioinformatics studies have shown that, hsa-miR-۲۰۵-۵p is predicted totarget the tp۵۳ gene and activate the apoptotic pathway, which helps to inhibit cancer. Accordingto the negative regulatory function of microRNAs, the expression of hsa-miR-۲۰۵-۵p is expectedto be increased and makes the expression of target gene to downregulate and cause cancer.

کلیدواژه ها:

pancreatic cancer ، tp۵۳ gene ، hsa-miR-۲۰۵-۵p