PARP۱ expression in sporadic triple-negative breast cancer using bioinformatics analysis

Background: Poly (ADP-Ribose) Polymerase ۱ (PARP۱) expression as a target for PARPinhibitors has been under great attention in hereditary ovarian and breast cancer.However, PARP۱ expression status, as a target for these new inhibitors, is uncertain in sporadictriple-negative breast cancer (TNBC), which is a poor prognosis subtype of breast cancer withoutany targeted therapy. In this study, the PARP۱ expression status was investigated as a potentialtreatment target in sporadic TNBC tumours compared with non-TNBC or normal breast tissuesamples using bioinformatics analysis.Materials and Methods: Three gene datasets (ID: GSE۶۵۱۹۴, GSE۷۶۲۷۵ and GSE۴۵۸۲۷) withbreast cancer and healthy breast tissue samples data (in total ۲۸۰ TNBC tumours in comparisonwith ۶۷ non-TNBC tumours and ۲۲ normal breast tissue) were downloaded from the GeneExpression Omnibus (GEO) database. The GEO۲R online tool was used to screen DEGs inwhich genes with adjusted P-value <۰.۰۵ and |log fold change (FC)| > ۰ were considered asDEGs. Finally, the expression profile of PARP۱ was determined among DEGs in all datasets.Results: Our results revealed significant overexpression of PARP۱ in the TNBC tumourscompared with non-TNBC and healthy breast tissue samples (adjusted P-value <۰.۰۵ andlogFC > ۰) according to bioinformatics investigation in gene expression datasets.Conclusion: It seems that the PARP۱ is overexpressed in sporadic triple-negative breast tumourscompared with non-TNBC and healthy breast tissue samples. This finding can suggest furtherinvestigation concerning the potential application of PARP۱ inhibitors for the treatment of theTNBC subtype of sporadic breast cancer in future clinical trials.

کلیدواژه ها:

PARP۱ expression ، TNBC ، Bioinformatics ، GEO