Biological connections between AHR gene and the genes involving in human skin aging

Backgrounds: The skin acts as a protective barrier between the internal organs/body theenvironment. Skin properties such as hydration, elasticity, and antioxidant capacity play a keyrole in the skin aging process. AHR (aryl hydrocarbon receptor) is one of the involving genes inskin aging. Exposure of keratinocytes and skin fibroblasts to ultraviolet radiation, tobacco smokeetc. increases the expression and activity of MMP-۱(matrix metalloprotease) in an AHRdependentmanner. As a result, activation of the AHR signaling pathway and increased CYPactivity, leads to the formation of free radicals (ROS), collagen breakdown and the formation ofwrinkles.Materials and Methods: A systematic literature review was performed to collect the genesrelated to skin hydration, elasticity, and antioxidant capacity. GeneMANIA algorithm was usedto recognize the biological connection among the genes. The gene network was created based onprotein-protein interaction, genetic interaction, co-localization and pathway.Results: We found ۵۵ genes associated with skin aging. Systematic analysis showed that AHRgene has a biological relationship with NFE۲L۲, IL۶, PTGS۲, CYP۱B۱, ALDH۱A۱ genes throughco-localization and physical interaction. Likewise, we observed JUN gene has the mostbiological connections with the other skin aging genes.Conclusion: This study shows that the AHR gene may be involved in the aging process of theskin by its antioxidant activity, elasticity, and its association with the other related genes. Itintroduces JUN gene as an important gene in skin aging. Our study provides insights about theprioritization of the genes are involving in skin aging.

کلیدواژه ها:

Skin aging ، AHR gene ، GeneMANIA ، gene network