Investigation of frequency of VKORC۱ gene polymorphisms in Warfarin treated patients in Rafsanjan

Backgrounds: Warfarin is one of the most important oral anticoagulants that are prescribed inthe process of preventing blood coagulation based on the needs of individuals. Age, sex, diet,used medications and most importantly genetic factors are important factors in determining thedose of Warfarin. Some VKORC۱ gene polymorphisms, which express the C۱ subunit of VKORvitamin K epoxide reductase, are responsible for Warfarin resistance and sensitivity. The presentstudy investigated the frequency of VKORC۱ gene polymorphisms in patients treated withWarfarin in Rafsanjan.Materials and Methods: In this cross-sectional study, -۱۳۶۹G>A gene polymorphism wasdetermined by PCR-RFLP method on ۱۱۳ patients taking Warfarin. Statistical analyzes wereperformed with SPSS software version ۲۵ to investigate the correlation between patients'demographic data and Warfarin dose.Results: After comparing the mean dose of Warfarin, there was no significant differencestatistically in the dose of warfarin with age and sex in relation to this polymorphism, but AAand GG genotype were required the lowest and the highest dose of warfarin in patients,respectively.Conclusion: It seems that in addition to the mentioned polymorphism, the relationship betweenWarfarin consumption and alleles of other genes as well as environmental conditions maydepend on their effect on Warfarin consumption. It needs to perform more studies.

کلیدواژه ها:

Anticoagulation ، Warfarin ، Genetic polymorphism ، VKORC۱