Bioinformatics evaluation of targetome LncRNA HOTAIR signaling pathways and related function of miR۱۲۹-۵p in breast cancer

Backgrounds: Breast Cancer (BC) is cancer that develops from breast tissue. about ۵ to ۱۰percent of cases are due to genetic predisposition inherited from the individual's parents,including BRCA۱, BRCA۲, and others. Worldwide, breast cancer is the most advanced type ofcancer in women, accounting for ۲۵% of all cases. In ۲۰۱۸, it resulted in ۲ million new cases and۶۲۷,۰۰۰ deaths. The disease is more common in developed countries and is more than ۱۰۰ timesmore common in women than men. The function of LncRNAs in BC involves RNA binding,degradation, transcription, and translation. They are involved in breast cancer by acting asinhibitors of tumors or tumor genes as well as interacting with DNA, RNA and proteins.Preliminary studies have shown that microRNA expression is characterized by abnormalities inmany diseases such as cancer. MicroRNA expression profiles were demonstrated by tumordevelopment, progression, and response to treatment, suggesting their potential use as diagnostic,prognostic, and predictive biomarkers.Materials and Methods: Based on bioinformatics databases and studies by The Cancer GenomeAtlas, LncRNA HOTAIR was selected to study breast cancer, then searched in various databasessuch as NCBI, mirbase, mirwalk, DAVID to achieve its goals.Conclusion: Overall, I predict that in people with breast cancer, the expression of LncRNAHOTAIR, should increase, thus inhibiting the miRNA۱۲۹-۵p, and ultimately increase the PRLRgene expression and activate the cancer pathways.

کلیدواژه ها:

Breast cancer ، LncRNAs ، MicroRNAs ، PRLR gene