Investigation of LNC HOTAIR in renal cell carcinoma and expression of this LNC

Backgrounds: Renal cell carcinoma is one of the most common cancers in the world that causesmany deaths every year. Epigenetic changes in non-coding RNAs, including LNC RNA, are aleading cause of cancer. HOTAIR is an LNC RNA which, it causes cancerous growth through anuncontrolled progression of the cell cycle and increased metastasis in some cancers.Materials and Methods: Our aim in this study was to investigate the role of this LNC RNA inthe incidence of renal cell carcinoma. To study, LNC RNA disease ۱ and LNC RNA disease ۲databases were selected and the role of this LNC RNA in renal cell carcinoma and itsrelationship with other LNC RNAs was investigated.Results: According to Disease Association Statistics, the highest score is related to LNCHOTAIR and this LNC has a significant expression in renal cell carcinoma and also theexpression of LNC HOTAIR is higher in people with tumors.Conclusion: LNC RNA is a long non-coding RNA with a size of more than ۲۰۰ nucleotides andcan’t be translated into protein. It also plays an important role in biological processes andregulation of gene expression and is used in understanding the biological sciences, especiallydiseases. This study is associated with HOTAIR LncRNA uptake and a strong association inkidney cancer and further expression of this Lnc in tumor cells.

کلیدواژه ها:

Lnc ، HOTAIR ، Renal carcinoma ، Gene ، Cancer