Autism and FOXP۲ gene involved

Backgrounds: A single genetic factor on ۷q۳۱ contributes to both autism and languagedisorders. FOXP۲ regulates the transcription of genes into messenger RNAs, or mRNAs, theprecursors of proteins — directing protein expression and repression during development. It isthrough these partner genes and their networks that FOXP۲ may have its greatest impact onspeech and autism.Materials and Methods: We used different sites. We specifically selected autism and a geneand LNC and examined each case carefully and got all the necessary information about them andwe obtained the association of the gene with the disease and SNP with the disease.Results: As disease expression increases, LNCs show different expressions. If ΔG bindingbecome zero or positive, it is in the interest of separation and the more negative it is in theinterest of connection.Conclusion: Autism has a strong genetic basis. FOXP۲ is contributes to autism and it hasdifferent SNPs. Autism has different LNCs that cause different diseases.

کلیدواژه ها:

SNP ، LNC ، Neurodevelopmental ، Polyglutamine ، Expression