Single nucleotide polymorphisms in BRCA۲ partial sequences associated with breast cancer in human

Backgrounds: Single nucleotide polymorphisms (SNPs) are a type of polymorphism involvingthe difference of a single base pair. Although single nucleotide polymorphisms usually occur incoding regions of genes and cause changes in the produced proteins and the resulting productwould have effects on health, they can be considered as genetic markers for the identification ofcancer genes. Breast cancer is a good example of those malignancies which may occur due tosingle nucleotide polymorphisms in women all around the world.Materials and Methods: Ten BRCA۲ gene sequences of human species were taken from theNCBI database. The alignment of these sequences was done by Multalin software and the resultswere analyzed to see whether there are any single nucleotide polymorphisms and reveal the exactregions that those polymorphisms have occurred.Results: The ten BRCA۲ gene sequences with the highest level of similarity (more than ۹۹%identity) in human spices were identified. They were about ۸۴۴۹ bp in length with ۱۳ singlenucleotide polymorphisms.Conclusion: Nucleotide BLAST search showed that despite frequent resemblances betweenthose sequences, some discrepancies could be seen among them as well. The nucleotides whichwere different can be considered as single nucleotide polymorphisms and can be used aboutbreast cancer in humans.

کلیدواژه ها:

Single nucleotide polymorphisms ، Breast cancer ، human ، Alignment ، BRCA۲ gene