Lesser known factors in having diabetes; focus on: aralkylamine Nacetyltransferase (AANAT)

Backgrounds: Today, the effect of HLA-DQA۱, HLA-DQB۱, and HLA-DRB۱ genes in thedevelopment of diabetes has been confirmed. In this study, we intend to examine the role ofaralkylamine N-acetyltransferase (AANAT) gene in having diabetes which is generally effectivein regulating circadian rhythms and melatonin levels.Materials and Methods: Two rats named I and II were tested. rat I was kept in a darkenvironment away from light. rat II were kept in a well-lit environment away from darkness.Both rats were kept in these environments for ۳ months. The rats were similar in age and arehealthy as well as the same diet. The number of insulin receptors, blood melatonin levels, andblood sugar levels was measured in two rats on a regular basis.Results: After three months, the level of blood melatonin in rat I increased from ۷.۵ mg to ۱۱.۳mg, in rat II, the level of blood melatonin decreased from ۶.۸ mg at the beginning of theexperiment to ۲.۱ mg at the end.measurements of insulin receptors in rats I and II show that by increasing melatonin levels,which means increasing the expression of AANAT, the number of insulin receptors dropped andblood sugar levels increased in rat I, in contrast, by decreasing expression of AANAT in rat Ipromote the number of insulin receptors increase.Conclusion: Due to changes in the level of Insulin with an increase or decrease in the expressionof the AANAT gene in rats, it seems that the AANAT gene is related to diabetes.

کلیدواژه ها:

AANAT ، diabetes ، Insulin ، Melatonin ، rat