Association of Serum Anti-Heat Shock Protein ۲۷ Antibody with Obesity Risk among Healthy Individuals in MASHAD Study

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 140

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شناسه ملی سند علمی:

JR_JCTM-10-3_002

تاریخ نمایه سازی: 11 مهر 1401

چکیده مقاله:

Introduction: The association between the serum antibody titer of several heat shock proteins (HSPs) and cardiovascular disease (CVD) risk factors so far has been the subject of several previous studies.Aim: To evaluate the association of adiposity indices and HSP-۲۷ antibody titers in healthy individuals.Materials and Methods: Overall ۴۸۲۳ individuals were recruited from Mashhad Stroke and Heart Atherosclerotic Disorders Study (MASHAD study), that included ۱۴۹۶ individuals with normal-weight (body mass index (BMI) <۲۵ kg/m۲), ۱۹۷۵ individuals with over-weight (BMI ۲۵-۳۰ kg/m۲), and ۱۳۵۲ individuals with obesity (BMI≥ ۳۰ kg/m۲).Results: The serum anti-HSP-۲۷ antibody titers were not significantly different among obese individuals [۰.۲۱ (۰.۱۱ – ۰.۳۴) absorbency unit (AU)], over-weight individuals [۰.۱۹ (۰.۱۰ – ۰.۳۳) AU] and normal-weight individuals [۰.۱۹ (۰.۱۰ – ۰.۳۳) AU].Conclusions: we have found no significant relationship among anti-HSP-۲۷ antibody concentration and degrees of adiposity among Iranian adults.

نویسندگان

Fatemeh Sadabadi

Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Zahra Asadi

Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Alireza Heidari Bakavoli

Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Susan Darroudi

International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

Maryam Saberi-Karimian

International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.

Saniya Saljoughian

Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Maryam Shahi

Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran.

Mohammad Safarian

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mohsen Nematy

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Gordon A. Ferns

Department of Medical Education, Brighton & Sussex Medical School, Brighton, BN۱ ۹PH, UK.

Majid Ghayour-Mobarhan

Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mohsen Mouhebati

Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

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