Investigation of genetic mutations in autism

Autism, or autism spectrum disorder (ASD) refers to a broad range ofconditions characterized by challenges with social skills, repetitivebehaviors, speech, and nonverbal communication. The onset of autism lastsfrom the age of ۳ until the end of a person's life. Autism is a heterogeneousdisease caused by the environment and genetics. In this study, the relevantinformation was searched from PubMed, Scopus, Google Scholar, andMagiran databases. Data analysis was performed qualitatively.Research has shown that more than ۹۰% of brain function abnormalities andautistic genetic behaviors are involved in the interaction of different genesand mutations in the disease. A number of studies have suggested thatmutations in the FMR۱ and RBFOX۱ genes are associated with autism andthat there may be a link between the Reelin gene and the disease. Otherresearch suggests that mutations in the NF۱ gene, abnormalities in thechromosome Ⅱ, and abnormalities in the gene encoding the protein Catenincan lead to autism and that patients are likely to lack the Neurexin ۱ gene.Since the most common cause of autism is genetic factors, it is important torecognize genetic mutations related to autism in the effective diagnosis andtreatment of this disease.

کلیدواژه ها:

Autism ، Genetic mutations ، Heterogeneous ، Nervous system