long non-coding RNAs in childhood acute lymphoblasticleukemia patients

Childhood acute lymphoblastic leukemia (cALL) is the most commonpediatric cancer and despite an ۸۵% cure rate, still represents a major causeof disease-related death in children. ALL is characterized by the rapidgrowth of abnormally developing lymphoid cells within the bone marrow,which restricts the production of normal blood cells. Long non-codingRNAs (lncRNAs) are defined as transcripts with lengths exceeding ۲۰۰nucleotides that are not translated into protein. Recently, lncRNAs due totheir involvement in vital oncogenic processes such as differentiation,proliferation, migration, angiogenesis, and apoptosis have attracted muchattention as potential diagnostic and prognostic biomarkers in leukemia. Wehave summarized the current literature on the function of lncRNAs inchildhood ALL. We investigated the PubMed/Medline and google scholardatabases.Fernando et al. showed that BALR-۲ correlates with overall survival andwith response to prednisone. lncRNAs BALR-۱, BRL-۶, and LINC۰۰۹۸were overexpressed in pre-B ALL cases, and that all of these genescorrelated with cytogenetic abnormalities, disease subtypes, and survivalsof B-ALL patients. Garitano-Trojaola et al. found ۴۳ lncRNAs abnormallyexpressed in ALL. Linc-PINT was downregulated both in T- and B-ALLcases. TEX۴۱ is an upregulated lncRNA in the case of B-ALL (potentialdiagnosis biomarker) in pediatric patients. CDKN۲B-AS۱ was up-regulatedin pediatric T-ALL peripheral blood mononuclear cells and other cells.lncRNAs might be utilized as diagnostic and prognostic biomarkers inleukemia. Exploring the mechanisms underlying lncRNA functions iscritical to recognize their contribution to biological processes involved incALL.

کلیدواژه ها:

Acute Lymphoblastic Leukemia ، long non coding RNA ، biomarker ، pediatric ALL ، BALR-۲