CAR-T Cell Therapy and Expectations
محل انتشار: کنفرانس بین المللی ژنتیک و ژنومیکس انسانی
سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 125
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شناسه ملی سند علمی:
CHGGE01_068
تاریخ نمایه سازی: 22 شهریور 1401
چکیده مقاله:
Chimeric antigen receptor (CAR) T-cell therapy can be an acceptabletreatment for HCS and malignancies of immune system cells. Car T- celltherapy has shown to sustain remissions in patients with refractory or inone’s with relapsed B-cell malignancy. But clinically we have not seenthese developments in solid tumors. Cause in solid tumors with CAR-t celltherapy we are facing with immune-suppressive tumor TME that it mayrecruit regulatory T-CELLS and TAMs and MDSCs that three of these canact as an inhibitory for car-t cells therapy and also malignant cells candirectly express these four ligands such as CTLA۴, PD-۱, LAG-۳, TLM-۳on tumor infiltering lymphocytes and block the car-t cell activity. We knowthe major problem in patients with relapses CD۱۹ negative can cure withimmunotherapy CD۱۹. Now with OAD (oncolytic adenoviruses) Perhapswe are able to decrease the challenges of CAR-T cells therapy in TMEthroughout selectively, infection, replicating in malignant cells. On theother hand, we have BiTE that they are a kind of anti-cancer drug withFDA approval for ALL that BiTE therapy has some problems for solidtumors that finally can lead to increased toxicities inpatients. Conclusion: a new generation of OAD-BiTE can activate andproliferation T cells upon infection of cancer cells so a combination of car-tcell therapy and an OAD-BiTE has the potential to overcome the limitationof CARs and BiTEs in solid tumors.
کلیدواژه ها:
نویسندگان
Pegah Khalifeh Mehrjardi
Department of Biology, Science and Arts University, Yazd, Iran
Fatemeh Dehghan
Department of Biology, Science and Arts University, Yazd, Iran
Seyed Mohsen Miresmaeili
Department of Biology, Science and Arts University, Yazd, Iran