Investigation of genetic mutations in thyroid cancer

Thyroid cancer is a common type of endocrine malignancy, and its incidencehas been steadily increasing in many regions of the world. Thyroidmalignancy is divided into ۴ categories in terms of tissue characteristics:papillary, follicular, medullary, anaplastic. Numerous genetic mutations havea fundamental role in the tumorigenesis of the thyroid. In this disease, thegenes involved in controlling cell proliferation and invasion are improperlymethylated which leads to tumor progression and malignancy.Relevant information was searched from databases including PubMed,Scopus, Scholar google, magician, and the data were analyzed qualitatively.Research shows that the prevalence of thyroid cancer varies withgeographical, environmental, and racial conditions, and that genetic mutationare effective in the development of this disease, such as Tp۵۳ mutations andrat oncogene radiation. The frequency of Tp۵۳ gene mutations in thyroidcancers is lower than the frequency of mutations in other cancers, and themutation in this gene is resistant to many drugs. It is also recommended thatpatients with MTC have regular monitoring of rat oncogene beam germlinemutations. Besides the environmental factors, other factors such as heredity orunique traits also increased gene proliferation and Improper activation ofcertain metabolic pathways causes thyroid gland tumor.

کلیدواژه ها:

Thyroid cancer ، genetic mutations ، regular monitoring of rat