Improvement of beta thalassemia symptoms byexamining the role of polymorphic markers
محل انتشار: کنفرانس بین المللی ژنتیک و ژنومیکس انسانی
سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 121
نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
CHGGE01_050
تاریخ نمایه سازی: 22 شهریور 1401
چکیده مقاله:
Beta thalassemia is an autosomal recessive disorder in which mutations ordeletions in the beta-globin chains occur that reduce or stop HbA(Hemoglobin A) synthesis. The disease is most frequent in the temperateregions of the world, The purpose of this study was to improve thesymptoms of beta-thalassemia by recognizing the factors that increase fetalhemoglobin (embryonic hemoglobin) again. the present study is a review bycollecting and analyzing related articles and related information collectedfrom Google Scholar, PubMed, Scopus, and SID sites.The results show that increased fetal hemoglobin (HbF) is dependent ongenes that play a regulatory role in the expression of cluster genes of betaglobin.The BCL۱۱A (B cell lymphoma ۱۱A) is involved in regulatinggamma-globin synthesis. Some polymorphisms in the BCL۱۱A gene canincrease fetal hemoglobin production and modulate the clinical phenotype ofthese patients. From the evidence obtained from the articles, it can beconcluded that polymorphisms are associated with fetal hemoglobin and canplay a role in predicting the clinical condition of the fetus as thalassemiamajor, intermediate or minor.
کلیدواژه ها:
نویسندگان
Mitra Ranjbar Maleki
Student of Laboratory Sciences, Member of Young and Elite Researchers Club ofIslamic Azad University, Zahedan, Iran.Health Clinical Sciences research Center, Zahedan branch, Islamic Azad University,Zahedan, Iran.
Maede Mohseni Gonbach
Student of Laboratory Sciences, Member of Young and Elite Researchers Club ofIslamic Azad University, Zahedan, Iran.Health Clinical Sciences research Center, Zahedan branch, Islamic Azad University,Zahedan, Iran.