Investigating the Role of Wnt/Β-Catenin SignalingPathway in Gastric Cancer

Gastric cancer (GC) is one of the most common and lethal cancers worldwide.More than ۹۵۰۰۰۰ new cases are diagnosed annually. Despite the decliningrate of GC incidence and advances in diagnosis, GC causes more than ۷۰۰,۰۰۰death annually, and a five-year survival rate is nearly ۲۰%. Molecularpathways of GC There are several cell signaling pathways playing a role ingastric carcinogenesis different cell signaling pathways that are involved inGC tumorigenesis, highlighting either the expression pattern or contributedmutations in related genes. This study aimed to investigate the Wnt/β-cateninpathway in gastric cancer.The study method is based on the articles on gastric cancer, which wereanalyzed by searching scientific databases such as Science Direct, Springer,Google Scholar, PubMed. the result showed Wnt signaling regulates differentcellular processes, including cell fate, movement, polarity, and organogenesis.There are three types of Wnt pathways. The first is a canonical or β-catenindependentpathway that involves the stabilization of the proto-oncogene β-catenin. The second is the planar cell polarity pathway that involves in cellciliogenesis. The last is the Wnt/Ca۲+- dependent pathway that stimulates theintracellular release of calcium and activates Ca۲+-dependent mediatorscontrolling cell movement and behavior. as a Conclusion, two signaling,including nuclear factor (NF)-kB and Wnt/β-catenin are dysregulated in ۷۰%of the GC patients. The Wnt pathway is a key element in cell proliferationduring both normal and cancerous GC development.

کلیدواژه ها:

Wnt/β-catenin ، gastric ، cancer ، signaling pathway ، (NF)-kB