The role of genetics in epilepsy

Epilepsy is a central neurological disorder or neurological disorder in whichthe activity of neurons in the brain is impaired and leads to seizures in theperson. Based on family studies, twin studies, and advances in genesequencing and statistical approaches, we now know that genetics plays avery important role in epilepsy. Epilepsy is five times more likely to occur inthe first-degree relatives of a person with the disease. Studies of twins haveshown a ۵۰-۶۰% adaptation rate in monozygotic twins and about ۱۵% intwins dizygotic, as well as between ۱ and ۱۰% of Down syndrome and ۹۰%of people with Angelman syndrome have epilepsy, which indicates the linkbetween the disease and other genetic diseases. Classifying epilepsies basedon genetic contributions to their etiology is to divide them into a single geneor Mendelian epilepsies and complex epilepsies.In this review study, searches were conducted in the electronic and scientificdatabases of PubMed, Google Scholar, and ISI, and authoritative articlesrelated to the subject were searched using the keywords Epilepsy,Neurogenetics, and Twins. Certainly, using neurogenetics can be moreaccurate in finding the root causes of other neurological diseases that are ofgenetic origin, which is the basis for progress in the discussion ofneurogenetic diagnosis. Genetics has great importance and effect in thediagnosis of epilepsy that by further study and research on genes associatedwith this disease can be used as molecular indicators in the early diagnosis ofthis disease. Also, using anthropological studies, this disease can be studied inother ethnic groups.

کلیدواژه ها:

Epilepsy ، Neurogenetics ، Twins