The function of Circulating microRNAs in pathogenesis ofiron overload in children with Transfusion-Dependent β-Thalassemia major

Tissue iron overload is a life-threatening scenario in children withtransfusion-dependent β-thalassemia major, miRNAs (miRNAs) that areinvolved in iron hemostasis could serve as therapeutic targets for control ofiron overload. MicroRNAs, short single-stranded RNAs, that are not codedfor protein are significant molecules involved in celldevelopment/proliferation, apoptosis, and differentiation . In the presentreview, we summarize the current literature on the function of CirculatingmiRNAs in the pathogenesis of iron overload. We investigate thePubMed/Medline and google scholar databases. In this summary, we mentiona number of the study that is considered the circulating miRNA as usefulnon-invasive diagnostic, prognostic, and therapeutic biomarkers for tissueiron overload in children with transfusion-dependent β-thalassemia majorand control.Significant down-regulation of miR-let-۷d and miR-۲۰۰b and up-regulationof miR-۱۲۲ was observed in TDT patients. And by extension, targeting mightserve as novel sensitive, specific and non-invasive predictor biomarkers forcellular damage under the condition of tissue iron excess. The otherinvestigation showed a markedly increased level of EV miR-۱۴۴ wasobserved in all TDT patient subgroups compared to healthy controls. It isclear they are sensitive, specific, and non-invasive biomarkers that canpredict excessive cellular damage at an early stage and guide clinicians onthe iron status in TDT patients .However, little research has been done in thisfield and it is necessary to use the expression profiles to further search forthese biomarkers and analyze their molecular function and their role inpathogenesis.

کلیدواژه ها:

Transfusion-Dependent Β-Thalassemia Major ، Children ، IronOverload ، Blood Transfusion ، Circulating miRNAs