Periodontitis Therapy with Periodontal-derived Stem Cells (PDSCs) for Dental Tissue Regeneration

Periodontitis is a severe gum infection that can lead to tooth loss and other serious health complications. Periodontal ligament stem cells (PDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration. The objective of this study was to assess the regenerative capacity of PDLSCs and osteoblasts differentiated from PDLSC among periodontal patients. This research was conducted from February ۱۷, ۲۰۱۹ to December ۱۱, ۲۰۲۱. A sample of ۳۰ patients with periodontal disease with bone disease (losing the study) was identified from the pilot study sample by means of conventional sampling. Randomly assigned to two sets of eyelids, ۱۵ subjects. Group A contained PDLSCs patients, while group B patients were a control group. After documenting surface markers measured upon cytometry, SCs were differentiated after their extraction as explained by the previous researchers. Defects are detailed with PDLSCs, blanks and fonts. After ۴ weeks, tissue documentations containing air, alizarin and BMP۴ staining, PGLAP gene, etc. RT-PCR preparation was used. The results of the current study for CD-۹۰, an autumnal stem cell marker, were avian strains in both groups. Alizarin red staining was performed to show mineral substances. RT-PCR confirmed the differentiation of chondrocytes and bone. The study concluded the posterior cells of PDLSCs (other cells) to function in soft and hard tissues.

کلیدواژه ها:

chondrocytes ، immunological parameters ، inflammatory disease ، PDL ، PDLSCs