Investigation of the endometrial receptivity status in experimental hypothyroid-induced female rats
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 25، شماره: 9
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 158
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شناسه ملی سند علمی:
JR_IJBMS-25-9_005
تاریخ نمایه سازی: 20 شهریور 1401
چکیده مقاله:
Objective(s): This study aimed to investigate hypothyroidism’s effects on endometrial receptivity, creating an experimental hypothyroidism model in female rats. Materials and Methods: To induce hypothyroidism in rats of Hipotiroid-ER and Treatment-ER groups, ۰.۰۵% ۶-propyl-۲-thiouracil was freshly added to their drinking water for ۸ weeks and then the endometrial receptivity model was applied and sacrificed on the fifth day. In the Treatment-ER group, after sc-administration of ۰.۸ µg/۱۰۰ g L-thyroxine for ۱۰ days, the endometrial receptivity model was applied to the rats and sacrificed on the fifth day. Results: In the histopathological evaluation, epithelial degeneration, vacuolization, enlargement of the uterine glands, and morphological disorders were observed in the endometrial layer of the Hypothyroid-ER group. However, these pathologies were significantly alleviated in the Treatment-ER group. Integrin β۳, integrin αvβ۳, LIF, and HOXA۱۰ immune reaction intensities were high in the Control-ER and Treatment-ER groups, while in the Hypothyroid-ER group, integrin β۳, integrin αvβ۳, LIF, and HOXA۱۰ immunoreactivity intensities were low. Also, while MUC۱ immunoreactivity was high in the Hypothyroid-ER group, it was low in the other groups. In biochemical analysis, a significant increase in the TSH and progesterone levels and a significant decrease in the FT۴, E۲, FSH, and LH levels in the Hypothyroid-ER group compared with the Control-ER group were observed. Also, all hormone levels were significantly ameliorated in the rats of the Treatment-ER group compared with the Hypothyroid-ER group. Conclusion: The results obtained showed that hypothyroidism had a significant effect on endometrial receptivity—the histopathological and biochemical changes caused by hypothyroidism in the experimental rat model were ameliorated with L-thyroxine treatment.
کلیدواژه ها:
نویسندگان
Elif Erbaş
Department of Histology and Embryology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey
Semin Gedikli
Department of Histology and Embryology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey
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