Dietary intake of homocysteine lowering vitamins in relation to psychological disorders in adults

Introduction: Mental disorders are one the leading causes of disability worldwide. Previous studies on the association between homocysteine lowering vitamins intake (B۶, folate and B۱۲) and mental disorders have inconsistent results. Therefore, we investigated the association of homocysteine lowering vitamins (B۶, folate and B۱۲) intake with psychological disorders (depression, anxiety, psychological distress) in Iranian adults.Methods and Materials: In this cross-sectional study, dietary intakes of ۳۲۹۹ adults were collected using a validated food frequency questionnaire. Participants were categorized based on quartiles of vitamin B۶, folate, and vitamin B۱۲ intake, that were adjusted for energy intake. Hospital Anxiety and Depression Scale (HADS) and General Health Questionnaire (GHQ), validated for Iranians, have been applied to assess depression, anxiety, and psychological distress.Results: Participants had a mean age of ۳۶.۳±۷.۹ years, of whom ۵۸.۵% were women. After considering potential confounders, adults in the top quartile of vitamin B۶ intake, compared to the bottom one, had decreased odds of anxiety (OR: ۰.۶۵, ۹۵%CI: ۰.۴۵–۰.۹۴), depression (OR: ۰.۶۱, ۹۵%CI: ۰.۴۶-۰.۸۱), and psychological distress (OR: ۰.۵۱, ۹۵%CI: ۰.۳۸–۰.۶۸). Also, individuals in the third tertile of vitamin B۱۲, compared to the first, intake had ۲۶% decreased odds of depression (OR: ۰.۷۴, ۹۵%CI: ۰.۵۵-۰.۹۹); however, no significant association was observed for anxiety (OR: ۰.۸۶, ۹۵%CI: ۰.۵۸–۱.۲۷) and psychological distress (OR: ۰.۷۸, ۹۵%CI: ۰.۵۷-۱.۰۶). Furthermore, there was not any significant association between the last quartile of folate intake and odds of anxiety (OR: ۰.۷۷, ۹۵%CI: ۰.۴۶–۱.۲۸), depression (OR: ۰.۷۶, ۹۵%CI: ۰.۵۲–۱.۱۱) and psychological distress (OR: ۰.۸۶, ۹۵%CI: ۰.۶۰–۱.۳۴) compared to the first quartile.Conclusion: We found vitamin B۶ intake to be inversely related to anxiety, depression, and psychological distress. Furthermore, vitamin B۱۲ intake was inversely associated with depression. However, no substantial relation was observed between folate intake to mental disorders. Further prospective studies are required to affirm our findings.

کلیدواژه ها:

Folate ، Pyridoxine ، Vitamin B۱۲ ، Depression ، Anxiety ، Psychological distress