Synthesis and Characterization of New Substituted Coumarin Derivatives and Study Their Biological Activity

New substituted coumarins derivatives were synthesized by using nitration reaction to produce ‎different nitro coumarin isomers which were separated from these isomers by using different solvent, and the ‎reduction of nitro compounds was done to give corresponding amino coumarins. Temperature and ‎reaction time of reaction were very important factors in determining the most productive nitro isotopes‎. A low temperature for three hours was sufficient to give a high product of a ‎compound ۶- nitro coumarin while increasing the temperature for a period of twenty-four hours that gave ‎a high product of ۸-nitro-coumarin. The synthesized compounds were confirmed by FT-IR, ۱H-NMR, and ‎۱۳C-NMR spectroscopy and all final compounds were tested for their antifungal and antibacterial activity. Some ‎of them showed more biological activity than the standard drugs. Some synthesized compounds ‎showed a variation in their anti-oxidant activities according to IC۵۰ values.  Some of these compounds had a ‎very good antioxidant compared with ascorbic acid as a standard.‎

کلیدواژه ها:

Coumarin ، Nitration ، reduction ، aminocoumarin ، Antioxidant