Synthesis of Novel Michael Adducts and Study of their Antioxidant and Antimicrobial Activities
محل انتشار: مقالات مروری و پژوهشی شیمی، دوره: 5، شماره: 4
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 93
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شناسه ملی سند علمی:
JR_CHRL-5-4_002
تاریخ نمایه سازی: 12 شهریور 1401
چکیده مقاله:
In the current study, the Michael addition reaction of nitromethane to chalcones were studied. ۴-benzeloxy benzaldehyde was synthesized from ۴-hydroxybenzaldehde and benzyl bromide, which was then converted to chalcone derivatives by reaction with substituted acetophenones, and finally nitromethane was added to give Michael adducts. The structures of the synthesized compounds were characterized by FTIT, ۱H NMR, and ۱۳C NMR spectroscopy. All the products were screened for antibacterial activities against Staphylococcus aureus G (+ve) and Escherichia coli G (-ve) microorganisms and antifungal activity against candida albicans besides their antioxidant activity.
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نویسندگان
Shikar Sherzad Othman
Department of Chemistry, College of Science, Salahaddin University - Erbil, Kurdistan Region - Iraq
Media Noori Abdullah
Department of Chemistry, College of Science, Salahaddin University-Erbil, Kurdistan Region - Iraq