Evaluation of Rats’ Biochemical Markers in Artemisia Annua Linn. Extract After Lead Toxicity

This research aimed to evaluate the impact of Artemisia annua L. (A. annua L.) on liver and kidney functions following lead-induced injury that was extracted from the plant by using ethanol. Forty male rats were divided into ۴ classes (ten rats per group), G۱ called negative regulation, G۲ administered ۱۵ mg/kg of lead acetate per day for ۱۵ days orally, G۳ administered A. annua L. extract at ۱۰۰ mg/ml IP for ۲ weeks, and G۴ administered ۱۵ mg/kg of lead acetate per day for ۱۵ days, and then handled A. annua L. at (۱۰۰ mg/kg b.wt) for two weeks. As a result of the procedure, blood samples were aspirated for serum isolation, the serum was used to estimate alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, and Urea. The present findings showed a significant (P≤۰.۰۵) increase in levels of AST and ALT in G۲ compared with G۱ and G۳ which showed normal values, while G۴ showed a significant decrease in ALT and AST levels as compared with G۱ and G۳, whereas G۴ displayed a significant (P≤۰.۰۵) reduction popular levels of urea, creatinine G ۲ related to G۱ and G۳ which revealed normal values.

کلیدواژه ها:

A. Annua L.extracted ، Rats ، lead toxicity ، biochemical markers