The effect of endurance training, consumption of green coffee and chlorogenic acid on glutathione, glutathione peroxidase and malondialdehyde

The present study investigated the effect of endurance training, green coffee supplement, chlorogenic acid supplementation on glutathione, glutathione peroxidase and malondialdehyde in skeletal muscle tissue of male C۵۷BL / ۶ mice. After induction of prediabetes in male C۵۷BL۶ mice (N = ۴۲), they were randomly divided into two groups of high-fat diet for induction of pre-diabetes and normal diet. They were divided into groups of green coffee, endurance training, endurance training and green coffee, chlorogenic acid, chlorogenic acid and endurance training (n = ۷). The training protocol was increasingly performed over ۱۰ weeks of ۳ sessions, each session lasting ۴۵ minutes at a speed of ۲۳ m / min on the turntable. Green coffee at a dose of ۲۲۰ mg / kg body weight three times a week Chlorogenic acid ۱۱۰ mg / kg body weight four times a week was given to the groups by gavage. ۲۴ hours after the last training session, consumption of green coffee and chlorogenic acid, quadriceps skeletal muscle biopsy was performed and after weight lifting, it was transferred to the laboratory to measure glutathione, glutathione peroxidase and malondialdehyde. One-way ANOVA test was used to evaluate the effect of exercise, coffee and chlorogenic acid and their simultaneous effect on dependent variables. The results showed that endurance training, green coffee, chlorogenic and their simultaneous effect on glutathione, glutathione peroxidase and malondialdehyde, had a significant effect (p <۰.۰۵). According to the findings of the present study, at a significant level of P <۰.۰۵, endurance training, green coffee and chlorogenic acid increase antioxidant activities and can reduce blood sugar and modulate metabolic pathways. Be effective in strengthening antioxidant systems.

کلیدواژه ها:

Prediabetes ، Endurance training ، Green Coffee ، Chlorogenic acid ، Glutathione ، Glutathione peroxidase ، Malondialdehyde. Oxidative stress