COMPARING SERUM LEPTIN AND ADIPONECTIN LEVELS IN CONTROLLED AND NON-CONTROLLED TYPE ۲ DIABETES

Abstract    INTRODUCTION: It has been demonstrated in recent studies that abnormal levels of adipocytokines may contribute to insulin resistance and type ۲ diabetes. The aim of the present study was to compare serum leptin and adiponectin levels in controlled and non-controlled type ۲ diabetes.       METHODS: ۱۱۷ patients with controlled and non-controlled type ۲ diabetes were studied. Patient, were divided into two groups based on their serum HbA۱c level; there were ۶۲ patients in the controlled group (۶ %< HbA۱c≤ ۸%) and ۵۵ patients in uncontrolled group (HbA۱c>۸%). Parameters like age, sex, duration of diabetes and biochemical indicators such as fasting blood sugar, HbA۱c, insulin resistance, leptin and adiponectin were determined.    RESULTS: Higher leptin and lower adiponectin levels were observed in non-controlled type ۲ diabetes. The levels of fasting blood sugar and insulin resistance were significantly higher in the non-controlled group (P<۰.۰۵).    CONCLUSION: Leptin and adiponectin may play an important role in the regulation of insulin sensitivity and control of type ۲ diabetes.         Keywords: Type ۲ Diabetes, Insulin resistance, Leptin, Adiponectin.