PARAXONASE (PON) ACTIVITY IN LESS THAN ۴۰ YEARS OLD NON- DIABETIC PATIENTS WITH AND WITHOUT SIGNIFICANT CORONARY ARTERY DISEASE

Abstract    INTRODUCTION: Regarding the increasing incidence of cardiovascular diseases (CAD) in people younger than ۴۰ years old, without any major risk factors, this study aimed to find if atherosclerosis of serum Paraxanase (PON) activity is a probable risk factor.    METHOD: This was a case-control study on ۸۰ non diabetic persons younger than ۴۰ years old, with chest pain. Patients were divided in two groups based on their results of coronary angiography test: patients with and without CAD (angoi-positive and angio-negative). We also divided patients based on major coronary artery disease risk factors in two groups: with and without risk factors. We measured and compared PON activity, body mass index (BMI), serum triglyceride (TG), fasting blood sugar (FBS), C- reactive protein (CRP), apolipoprotein A۱ and B (APO A۱, and APO B), total cholesterol and low and high density lipoproteins (LDL and HDL) together in these groups.    RESULTS: In angio-negative and angio-positive groups, the difference between PON activity (۱۲۱.۴۴ vs. ۸۹.۵۸), HDL (۴۴.۵۸ vs. ۳۷.۱۱), TG (۱۴۹.۳۱ vs. ۱۹۹.۷), APO B (۸۷.۴۸ vs. ۹۹.۵۰), CRP (۴.۳۸ vs. ۷.۳۲) was significant (P < ۰.۰۵). There was not seen any significant difference between two groups regarding LDL, total cholesterol, APOA, and BMI (P > ۰.۰۵). We didn’t find any relationship between PON activity and HDL levels.     CONCLUSION: This study suggests that low PON activity level might be considered as a risk factor for coronary artery disease, especially in patients who don’t have any other major risk factors. Further studies are needed to evaluate the effect of these risk factors on each other.      Keywords: Paraoxonase activity, CRP, BMI, triglyceride, APO A۱, APO B, HDL, LDL and total cholesterol, coronary artery disease.