Changes in serum lipid profile of obese or overweight children and adolescents following a lifestyle modification course

BACKGROUND: Considering rapid global increase in children obesity and high prevalence of dyslipidemia in obese and overweight children, this study aimed to evaluate the effect of an educational course on changes of lipid profile in children.    METHODS: This non-pharmacological clinical trial study was performed on ۴-۱۸ year-old children attending outpatient clinics of Isfahan Endocrine and Metabolism Research Center (Iran). Anthropometric measurements were conducted for all children. Fasting blood samples were taken from right hand of the participants at the first laboratory visit. Biochemical tests including measurement of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were also carried out. Children took part in one educational session in which they were taught about ways and benefits of having regular physical activity once a day and having healthy foods. All children were followed up for about four months and anthropometrics and biochemical tests were repeated. Data was analyzed using SPSS۱۶.    RESULTS: A total number of ۴۱۲ children (۲۴۵ girls and ۱۶۷ boys) were divided into four age groups of under ۶, ۶-۹, ۱۰-۱۳, and ۱۴-۱۸ years old. Baseline anthropometric measures were significantly higher in boys. However, there was no difference between boys and girls in baseline lipid profile. Children's body mass index (BMI) z-score increased in all age groups except for ۱۴-۱۸ year-old boys. In boys older than ۱۰ years, there were significant reductions in LDL-C and TC. In girls over ۱۰ years of age, there was a significant increase in HDL-C. Although anthropometric measurements did not change in children (except for ۱۴-۱۸ year-old-boys), there was a significant reduction in children's lipid profile after the study.    CONCLUSION: Our study showed that although one session of interventional education had no significant effects on children's anthropometric measurements, it could change their lipid profile. Moreover, the intervention was more effective on improving lipid profile in children over ۱۰ years of age. Therefore, effective interventional strategies must be invented and implemented on children based on their age group.      Keywords: Children Obesity, Education, Anthropometry, Lipid Profile, Lifestyle.