Platelet indices and function response to two types of high intensity interval exercise and comparison with moderate intensity continuous exercise among men after coronary artery bypass graft: A randomized trial

BACKGROUND: It has been indicated that the acute exercise increases the thrombotic events that stem from platelet hyper-reactivity. The present randomized controlled trial study was carried out with the aim to compare high-intensity interval exercise (HIIE) with moderate intensity continuous exercise (MICE) in terms of platelet indices and function in patients who had undergone post coronary artery bypass graft (CABG).METHODS: ۳۰ men with a history of CABG were recruited and divided into ۳ groups (MICE, HIIE-۱, and HIIE-۲). The MICE protocol consisted of running for ۴۰ minutes with ۶۵% of maximal heart rate (HRmax). Subjects in HIIE-۱ group performed an interval exercise with work to rest ratio of ۱:۱ in which ۱۰ rounds of running (۹۵% HRmax) were followed by active recovery (۳۵% HRmax). HIIE-۲ subjects performed an interval exercise with work to rest ratio of ۲:۱ in which ۷ rounds of running (۸۵% HRmax) were followed by active recovery (۴۵% HRmax). Before and immediately after the exercise protocols, blood samples were taken from subjects and analyzed to measure the variables.RESULTS: Although platelet count (PLT) and hematocrit (HCT) were increased significantly after HIIE-۱ and HIIE-۲ in comparison to MICE (P < ۰.۰۵۰), the other platelet indices [mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT)] were not significantly changed among groups (P > ۰.۰۵۰). The platelet aggregation and fibrinogen were further increased after HIIE-۱ and HIIE-۲ as compared with MICE; however, such increment were significant between HIIE-۲ and MICE (P < ۰.۰۵۰).CONCLUSION: It seems that HIIE, regardless of the type, has higher thrombotic potentials compared with MICE. Accordingly, MICE is safer than HIIE for rehabilitation in patients undergoing CABG.

کلیدواژه ها:

High-intensity Intermittent Exercise ، Aerobic Exercise ، Rehabilitation ، Platelets ، Fibrinogen