IMPACT OF HELICOBACTER PYLORI ON PROGNOSIS OF PATIENTS WITH ACUTE CORONARY SYNDROME

AbstractINTRODUCTION: Coronary artery disease (CAD) is the main cause of mortality inindustrial and developing countries. New risk factors including infections are underinvestigation as potential factors. One of these infectious agents is Helicobacter pylori,which has been investigated in numerous studies. This study was designed in view of thecontroversies surrounding the impact of Helicobacter pylori on the prognosis of patients withacute coronary syndrome (ACS).METHODS: All patients with ACS including unstable angina and myocardial infarction whowere referred to Fatemieh Hospital between ۲۰ February ۲۰۰۳ and ۱۹ February ۲۰۰۴ andwere admitted to the CCU ward were enrolled in this cohort study. A total of ۴۱۱ patientswith ACS were evaluated for Helicobacter pylori serologically, and the occurrence of cardiacevents needing angioplasty or coronary surgery was assessed.RESULTS: Mean age of patients was ۵۹.۹۷±۳۸.۱۲ years and ۵۶% of them were male. Theserology test for Helicobacter pylori infection was positive in ۴۵.۶±۱۲.۳۸%, negative in۴۳.۸%, and borderline in ۱۰.۶% of patients. ۱۹۱ patients had unstable angina and ۲۲۰patients had myocardial infarction. In a one-month follow-up, ۱۰% of the patients developedcardiac events and PCI or CABG was performed in ۶.۱% (۱۶.۱% totally). One-monthoccurrence of cardiac events in the group with Helicobacter pylori infection was ۱۱.۹% vs.۱۹.۳% in the group without infection (χ۲ =۳.۰۷۸, P=۰.۰۷۹).DISCUSSION: This prospective study showed that Helicobacter pylori infection has noeffect on short term prognosis of patients with ACS.ARYA Journal, ۲۰۰۵, ۱(۳): ۱۶۴-۱۶۹Keywords • Helicobacter pylori • Acute coronary syndrome • Prognosis