The relation between vitamin D status and anemia in patients with end stage renal disease on regular hemodialysis

Introduction: Anemia is a common complication in end-stage renal disease (ESRD) patients on regular hemodialysis (HD). There has been a lot of interest recently in the non-classical effects of ۲۵(OH) vitamin D (calcidiol), including its association with erythropoiesis and anemia pathogenesis.Objectives: To study the relation between anemia and vitamin D status in patients on regular HD.Patient and Methods: This study is a cross-sectional study that included ۹۰ patients on regular HD. Vitamin D status was classified into deficient (<۲۰ ng/mL), insufficient (۲۰-۳۰ ng/mL) and sufficient (>۳۰ ng/mL).Results: The level of vitamin D measured in the patients ranged between ۳.۵ to ۶۶ ng/mL with median of ۱۶.۳۵ ng/mL. There were statistically significant positive correlations between vitamin D levels and the level of hemoglobin (P < ۰.۰۰۱), serum calcium levels (P < ۰.۰۰۱) and serum PO۴ levels (P = ۰.۰۲۳). Higher hemoglobin levels were statistically related to both higher vitamin D values (P < ۰.۰۰۱) and higher serum calcium concentration (P < ۰.۰۰۱). Meanwhile, a significant negative correlation was found between hemoglobin levels and serum PTH values (P < ۰.۰۰۱).Conclusion: There was a significant association between the status of vitamin D and the level of hemoglobin in dialysis population who were studied, independent from iron status. other associations with hemoglobin levels included PTH level and calcium.

کلیدواژه ها:

Vitamin D ، Calcidiol ، Anemia ، Dialysis ، End-stage renal disease