Uric acid is an index of chronic diseases or is an index of antioxidant? A mini-review to the recent trends

Abnormal levels of serum uric acid are referred as a main public health problem arising from its role in systemic diseases including cardiovascular disease, chronic kidney disease, hypertension, type ۲ diabetes mellitus, ischemia, Alzheimer’s disease and Parkinson’s disease. Although uric acid is known as an index of chronic diseases, it is also referred as an antioxidant index especially in control of cardiovascular defects. Hence, it seems that uric acid is a double-edged sword. This mini-review is aimed to clarify the pathogenic effect of uric acid on some organs and its positive influence on cardiovascular system.

کلیدواژه ها:

Uric acid ، Chronic kidney disease ، Hyperuricemia ، Type ۲ diabetes mellitus ، Antioxidant ، Oxidative stress ، Cardiovascular disease ، Inflammation ، Reactive oxygen species