Publication of the First Issue of Journal of Human Genetics and Genomics: Message from the Editor-in-Chief

After completion of human genome project (HGP)many scientists realized that obtaining a genome‘blueprint’ alone is not sufficient to solve all issues relatedto human health (۱). HGP and subsequent projectslike encyclopedia of DNA elements (ENCODE), internationalHapMap, encyclopedia of gene and gene variants(GENCODE), functional analysis program, and others assignedfunctions for much of the human genome, whichwere thought to be useless intergenic DNA. Thus, unprecedentedscientific advent of HGP launched an entirely newspectrum of knowledge, offering tremendous potential toimprove global health. In light of the HGP, scientists cannow access and develop more sophisticated approaches toidentify and record the genetic contributions to multitudeof monogenic disorders and common, complex diseases(۲). To illustrate, as a product of the HGP, approximately۲۵,۰۰۰ annotated genes in the human genome as wellas mutations in over ۳,۰۰۰ genes have been linked to formonogenic and common polygenic diseases and moredisease-relevant genetic variations are being characterizedat a rapid pace. The abundance of genetic informationhas made it possible to identify potential therapeuticapproaches for genome editing or gene targeting as well(۳).

کلیدواژه ها:

Genetics ، Genomics ، Genome-Sequencing