The Prevalence of HPV and non-HPV STIs Among Iranian Women and Assessment of the HPV/non-HPV STIs Co-infection on Cervical Cell Changes

Background & Objective: Persistent infection with some types of Human papillomavirus (HPV), which are high-risk genotypes, can lead the patients toward cervical cancer and, finally, death. Recent studies showed HPV co-infection with non-HPV sexually transmitted infections (non-HPV STIs) could increase the persistency rate of HPV infections. This study aimed to estimate the prevalence of STIs and assess the association of HPV/non-HPV STIs co-infection on cervical cell changes based on cytological findings. Materials & Methods: In this cross-sectional study, in addition to the routine cervical screening, including HPV testing and cytological assessment, non-HPV STI testing was performed on ۱۰۶۵ Iranian women. To assess the HPV and non-HPV STIs, commercial kits were used. Results: ۹۶۴ (۹۰.۵%) women had normal cytology (NILM) results. The overall prevalence of HPV and non-HPV STIs were ۳۹.۱% and ۶۸.۵%, respectively. HPV-۵۳ (۶.۵%), -۱۶ (۶.۱%) and -۳۱ (۵.۵%) were found as the most prevalent genotypes. Ureaplasma Parvum (UP) (۴۲.۷%), Group B Streptococcus (GBS) (۲۳.۷%), Candida Species (CS) (۲۳.۶%), Ureaplasma Urealyticum (UU) (۹.۶%), and Mycoplasma Hominis (MH) (۷.۱%) were found as the most prevalent non-HPV STIs. The co-infection of HPV with GBS played an important role in developing the cervical lesion (P<۰.۰۵). Conclusion: In the present study, the STIs, including HPV, UP, GBS, CS, UU, and MH, were prevalent among the study participant, and it was found that the HPV/GBS co-infection played a significant role in the development of LSIL or worse cytological grades. To clarify this issue, further studies will be conducted.

کلیدواژه ها:

Cervical Lesions ، Co-infections ، Group B Streptococcus (GBS) ، Human Papillomavirus (HPV) ، Sexually Transmitted Infection (STIs)