Molecular Clock and Autoimmune Diseases; An Approach to Rheumatoid Arthritis; A Review

Circadian clock refers to a biological cycle that fluctuates in a period of ~۲۴ hours.These cycles are supported by a molecular clock and provide a temporal timerelatedmatrix that ensures the collocation of homeostasis processes with the courseof environmental changes. Here in this mini-review, we are going to summarize allrecent finding from the last five years till date in the field of circadian andevolutionary clock research in approach to rheumatoid arthritis as the world’s mostprevalence autoimmune disease with rate of over ۷۶ million in world populationand prevalence of near ۰.۶% of US which is almost ۱.۲۹ million people in theyear ۲۰۱۵. Rheumatoid arthritis shows a verity of symptoms besides morningstiffness and increased joint pain in the early morning. This morning joint andstiffness aca correlate to an elevated level of pro-inflammatory cytokines includeinterleukin-۶. The  circadian clock has a regulatory role in activity and expressionof proteins and their gene which comes under cycle which takes part in autoimmunedisease expression and progression, such as fat-derived adipokines and few nuclearreceptors. Based on current knowledge which expanding each and every momentwe know the pathways that how inflammatory responses regulated base on thatworking in a new age in the treatment of autoimmune disease especially rheumatoidarthritis.

کلیدواژه ها:

autoimmune disease ، cancer ، circadian clock ، nuclear receptors ، rheumatoid arthritis