The Relationship between Bone Mineral Density and Serum Vitamin D Levels in Cystic Fibrosis Children

Background: Cystic fibrosis is a multisystemic disorder. It is the most common autosomal recessive disorder in whites that causes complications such as changes in bone density. Therefore, evaluating bone densitometry and serum levels of vitamin D in children with cystic fibrosis is the aim of our study. Methods: This study was performed on ۵۴ children with cystic fibrosis. After recording demographic information, bone densitometry and serum levels of vitamin D were recorded. Chi-square and Pearson correlation tests were used to compare data. Results: Based on our study ۵۳.۷% of patients with CF had vitamin D less than ۲۰ nmol / l. It was also found that based on lumbar BMD, ۲۰.۳% had a BMD less than ۲.۵ - Based on femoral BMD, ۱۸.۵% had a BMD less than -۲.۵. And our results demonstrated that there is no relation between BMD with vitamin D, calcium and phosphorus but it is significantly correlated with age, height, weight, and BMI. Conclusion: Decreased BMD is high in patients with CF; on the other hand there is a deficiency of vitamin D in more than ۵۰% of these patients to whom vitamin D supplements should be prescribed along with the standard treatments. Further studies are also required to investigate the effect of other factors on BMD.

کلیدواژه ها:

Bone densitometry ، Vitamin D ، Cystic fibrosis