ApInAPDB: A database of apoptosis-inducing anticancer peptides

سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 284

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

IBIS10_005

تاریخ نمایه سازی: 5 تیر 1401

چکیده مقاله:

ApInAPDB (http://bioinf.modares.ac.ir/software/ApInAPDB) is manually-collected database of ۷۷۵apoptosis-inducing anticancer peptides accumulated from published research articles and databases likeDRAMP. ApInAPDB include ۷۴۸ linear and ۲۷ cyclic peptides having L-amino acids, D-amino acids or bothof them. The current version of the database provides information related to a peptide including source, Nterminalmodification, C-terminal modification, non-natural amino acid presence, binding target, function,IC۵۰ of peptide, cell lines, and finally binding affinity and etc. Additionally, several physicochemicalproperties such as isoelectric point, net charge at pH ۷, hydrophobicity and GRAVY among others and also۱۵۵۹ descriptors for QSAR modeling are calculated for almost all peptides. Besides, secondary structure ispredicted using Chou-Fasman, GOR, Neural Network algorithms and joint of them. Some user-friendlysearching tools are designed to facilitate browsing and achieving the desired results including simpleresearch, advanced research and top categories. Overall, ApInAPDB is the first database providescomprehensive and useful information of apoptosis-inducing anticancer peptides which can be helpful forresearchers interested in cancer therapy and peptide design.

کلیدواژه ها:

نویسندگان

Naser Faraji

Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Alireza Doustmohammadi

Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Seyed Shahriar Arab

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James CookUniversity, Cairns, Queensland ⁴⁸⁷۰, Australia

Norelle L Daly

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James CookUniversity, Cairns, Queensland ⁴⁸⁷۰, Australia

Ahmad Yari Khosroushahi

Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran