The Promising Role of MicroRNAs, Long Non-Coding RNAs and Circular RNAs in Urological Malignancies

Nowadays, non-communicable diseases are the leading cause of death worldwide. Cancer management has been a significant challenge for public health in the last decade. The aging of the population and Urbanization have induced significant alters in population structure and increased the burden of non-communicable diseases, like cancers. For several years, cancer genomics studies traditionally focused on coding genes. An explosion of studies into non-coding RNAs biology has shown that they could function as tumor suppressors and oncogenic drivers in nearly all cancer types. As a result, the uncovering of the role of functional RNAs in the formation and development of cancers is a promising frontier of cancer genetics.

کلیدواژه ها:

Non-coding RNA ، ncRNA ، lncRNA ، miRNA ، circRNA