Non-Cutaneous Melanoma, Findings and Prognostic Value of FDG PET/CT: A Case Series of ۲۳ patients and review of the literature

Objective(s): Non-cutaneous malignant melanomas (NCM) are rare malignancies. Due to their nonspecific symptoms, they present later in life. The value of FDG PET/CT in this group of patients is not clear. The aim of this study is to assess the role of FDG PET/CT in the management of NCM and its prognostic implication.Methods: We retrospectively selected twenty-three patients with a diagnosis of NCM evaluated with FDG PET/CT in Shariati hospital between ۲۰۱۹ and ۲۰۲۱. The PET/CT data were reviewed and compared with available conventional imaging findings. Five patients died within five months. The surviving patients were followed within a time interval of ۷ to ۲۷.۵ months after their PET/CT study, regarding their disease status.Results: Among ۲۳ patients (۸ ocular, ۵ sinonasal, ۳ pharyngeal, ۲ anorectal, ۲ vulvovaginal, and ۳ unknown primaries), PET/CT was able to detect residual primary disease, assess treatment response, and reveal or exclude metastases. Additional lesions compared to conventional imaging were found in five, while in one with brain metastases PET/CT was unable to detect lesions on MRI.  Thirteen patients had negative PET/CT finding of which ۱۱ (۸۵%) did not have remarkable finding on follow-up. Metastatic disease was recognized in eight. Patients with extensive metastases on FDG PET/CT had a poorer outcome.Conclusion: Similar to cutaneous melanoma, PET/CT is valuable in the management of NCM patients and is superior to conventional imaging modalities, with the exception of brain metastases. Patients with negative PET/CT findings have a better outcome as opposed to patients with significant positive PET/CT findings.

کلیدواژه ها:

non-cutaneous melanoma ، PET/CT ، Metastases ، Prognosis