Preparation and in vitro evaluation of controlled release granules of mesalazine for colon targeted drug delivery system

سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 77

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شناسه ملی سند علمی:

JR_TIPS-8-1_005

تاریخ نمایه سازی: 28 اردیبهشت 1401

چکیده مقاله:

Targeted drug delivery systems into the colon to cure different local diseases like ulcerative colitis, cancer, and irritable bowel diseases have gained attention. These drug delivery systems are more effective for local inflammation and have limited side effects. The purpose of the present study is to formulate a controlled-release system of mesalazine, an anti-inflammatory agent by fluidized bed coating. The formulation was prepared using hydroxyl propyl methylcellulose as sustained delivery and cellulose acetate phthalate for enteric-coated behavior. The prepared granules were evaluated for particles size, moisture content, friability, dissolution test. The granules made with wet granulation had a suitable size and free flowability with carr's index lower than ۲۰. It was concluded that the prepared granules could be successfully formulated with the use of release retarding polymers. The formulation showed appropriate release retardation of the drug, indicating the potential of a delivery system. A further investigation like capsule preparation and microbial count examination is needed for better evaluation of the formulation. Please cite this article as: Sanaz Mehdi-alamdarlou, Negin Mozafari, Saeid Daneshamouz, Hajar Ashrafi. Preparation and in vitro evaluation of controlled release granules of mesalazine for colon targeted drug delivery system. Trends in Pharmaceutical Sciences. ۲۰۲۲;۸(۱):۳۷-۴۲ .doi: ۱۰.۳۰۴۷۶/TIPS.۲۰۲۱.۹۲۹۵۴.۱۱۱۶

نویسندگان

Sanaz Mehdi-alamdarlou

Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.

Negin Mozafari

Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.

Saeid Daneshamooz

Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.

Hajar Ashrafi

Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.

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