Hydroxyapatite functionalized sulfonic acid a green and efficient heterogeneous catalyst for the preparation of ۳,۴,۵-substituted furan-۲(۵H)-ones

Hydroxyapatite functionalized sulfonic acid (HAp@SO۳ H) was synthesized and employed for the preparation of ۳,۴,۵-substituted furan -۲(۵H)-ones using multicomponent reaction (MCR). Optimized conditions was selected by employing of novel HAp@SO۳H as catalyst. The results showed that present novel acidic catalyst was very efficient and recyclable catalyst for the preparation of substituted furans. Cleaner reaction profile, mild reaction conditions, use of the green solvent and reusability of the catalyst, make this protocol attractive for the large scale synthesis of substituted furans.

کلیدواژه ها:

Hydroxyapatite ، Multicomponent reaction ، Catalyst ، Furane