Comparison of the effects of alcoholic extract of aerial parts of Anvillea garcinii and atorvastatin on the lipid profile and thyroid hormones in hypercholesterolemic rats
محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 12، شماره: 2
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 279
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شناسه ملی سند علمی:
JR_AJP-12-2_001
تاریخ نمایه سازی: 7 اسفند 1400
چکیده مقاله:
Objective: Decreased thyroid hormones along with increased blood fats and overweight, lead to atherosclerosis and eventually cardiovascular disease. The aim of this study was to compare the effects of alcoholic extract of aerial parts of Anvilea garcinii and atorvastatin on the lipid profile and thyroid hormones in hypercholesterolemic rats.Materials and Methods: In this study, ۴۰ male Wistar rats were divided into ۵ groups (n=۸): control, hypercholesterolemic vehicle and three experimental groups. The control group, received water and normal food daily, the hypercholesterolemic vehicle group received drug solvent (atorvastatin dissolved in distilled water) and three experimental groups received alcoholic extract of A. garcinii (۱۰۰ and ۳۰۰ mg/kg) and atorvastatin (۱۰ mg/kg) as gavage. At the end of the ۴۵- day period, blood samples were prepared from all groups and the amount of desired factors was measured and analyzed.Results: The amount of lipid profiles (cholesterol, HDL, LDL, VLDL,TG) and thyroid stimulating hormone in the vehicle group were increased compared to the control group, while the amount of these factors were decreased in the experimental groups compared to the vehicle group. Furthermore, the level of thyroid hormones in the hypercholesterolemic vehicle group was decreased compared to the control group, while the level of these hormones was increased in the experimental groups receiving the extract compared to the vehicle group.Conclusion: Alcoholic extract of A. garcinii aerial parts, may increase thyroid hormones, and sequentially reduce blood lipids; thus, it could be a good candidate for the treatment of hypercholesterolemia and hypothyroidism.
کلیدواژه ها:
نویسندگان
Fatemeh Rasekh
Department of Biology, Payame Noor University, Tehran, Iran
Zohre Atashi-Nodoshan
Department of Biology, Payame Noor University, Tehran, Iran
Ali Zarei
Department of Physiology, Estahban School of Paramedical Sciences, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran
Amir Abbas Minaeifar
Department of Biology, Payame Noor University, Tehran, Iran
Saeed Changizi-Ashtiyani
Department of Physiology, Arak University of Medical Sciences, Arak, Iran
Zahra Afrasyabi
Department of Midwifery, Islamic Azad university of Estahban, Shiraz, Iran