Hepatoprotective Effects of Chitosan and Chitosan Nanoparticles Against Biochemical, Genetic, and Histological Disorders Induced by the Toxicity of Emamectin Benzoate
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 166
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شناسه ملی سند علمی:
JR_RBMB-10-3_020
تاریخ نمایه سازی: 25 بهمن 1400
چکیده مقاله:
Background: Emamectin benzoate (EMB) is a biopesticide which used in agriculture as an insecticide. It is easier to reach ecologically and affects human health. This study aims to evaluate the protective effect of chitosan and chitosan nanoparticles against EMB-induced hepatotoxicity.
Methods: Male mice were distributed into four groups: G۱: the negative control, G۲: EMB group (۵ mg/kg diet), G۳: EMB with Chitosan, (۶۰۰ mg/kg diet), and G۴: EMB with Chitosan nanoparticles (۶۰۰ mg/kg diet). The experiment continues for ۸ weeks, and the animals were sacrificed, and their organs were removed and immediately weighed after sacrifice. The liver was quickly removed and processed for histopathological and genetic studies.
Results: Emamectin benzoate (EMB) treatment induced oxidative stress by increased levels of Malondialdehyde (MDA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with inhibition of acetylcholinesterase (AChE), Superoxide dismutase (SOD) and Catalase (CAT) levels. EMB produced several histopathological changes in the liver. Relative expressions of studied genes elevated in the liver with increase in DNA damage. Co-treatment with chitosan and chitosan nanoparticles reduced EMB related liver toxicity that belong to biochemical, histopathological, gene expression, and DNA damage by increasing antioxidant capacity.
Conclusions: This study offers insight into the potential for Chitosan and chitosan nanoparticles as a novel natural material against the oxidative stress induced by EMB.
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نویسندگان
Sherifa Fathalla Dawoud
The Biological and Environmental Sciences Department, Faculty of Home Economic, Al-Azhar University, Tanta, Egypt.
Tarek Mostafa Al-Akra
Agric. Zoology and nematology Department, Faculty of Agriculture, Al-Azhar University, Egypt.
Amina Mohamed Zedan
The Biological and Environmental Sciences Department, Faculty of Home Economic, Al-Azhar University, Tanta, Egypt.
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