Analysis of Micro-RNA-۱۴۴ Expression Profile in Patients with Multiple Sclerosis in Comparison with Healthy Individuals

Background: Etiology of multiple sclerosis is non-clarified. It seems that environmental factors impact epigenetic in this disease. Micro-RNAs (MIR) as epigenetic factors are one of the most important factors in non-genetically neurodegenerative diseases. It has been found MIR-۱۴۴ plays a main role in the regulation of many processes in the central nervous system. Here, we aimed to investigation of MIR-۱۴۴ expression alteration in Multiple sclerosis (MS) patients.  Methods: In this study ۳۲ healthy and ۳۲ MS patient's blood sample were analyzed by quantitative Real-Time PCR method and obtained data analyzed by REST ۲۰۰۹ software.  Results: Analysis of Real-Time PCR data revealed that miR-۱۴۴ Increase significantly in MS patients compared to healthy controls. Conclusions: The increase of MIR-۱۴۴ expression in MS patients is obvious. MIR-۱۴۴ can be used as a biomarker of MS and help to early diagnosis and treatment of this disease.

کلیدواژه ها:

MicroRNA (miRNA) ، MiRNA-۱۴۴ ، Multiple Sclerosis (MS).