The Benefits of Curcuminoid to Expression Nuclear Factor Erythroid ۲ Related Factor ۲ (NRF۲) and Signal to Noise Ratio (SNR) Value in the Noise Exposed Organ of Corti of Rattus Norvegicus

Background: Noise-induced hearing loss (NIHL) can cause damage to the cochlea. Curcumin and nuclear factor erythroid ۲-related factor ۲ (NRF۲) are transcription activators that play a crucial role in defence mechanisms against oxidative stress. The aim of this study was to determine the effect of curcuminoid administration on NRF۲ expression, in the organ of Corti of cochlea of Rattus norvegicus that were exposed to noise, from the results of the distortion product otoacoustic emission (DPOAE) examination. Methods: We divided ۳۶ rats into six groups including Group ۱ (control); Group ۲ (noise exposure without curcuminoid administration); Group ۳ (noise exposure+curcuminoid dose ۱۰۰ mg/day for four days); Group ۴ (noise exposure+curcuminoid dose ۲۰۰ mg/day for four days); Group ۵ (curcuminoid dose of ۱۰۰ mg/day for ۱۴ days followed by two days of noise exposure); Group ۶ (curcuminoid dose ۲۰۰ mg/day for ۱۴ days followed by two days of noise exposure).  Results: Following noise exposure in rats, there was an effect/correlation between NRF۲ expression, the SNR values obtained from DPOAE and curcuminoid administration. Conclusions: There was a correlation between curcuminoid administration, NRF۲ expression and DPOAE treatment. Following noise exposure in rats (Rattus norvegicus), SNR values obtained from DPOAE showed improved cochlear function.

کلیدواژه ها:

Curcuminoid ، Distortion Product Otoacoustic Emission ، Noise Induced Hearing Loss ، Oxidative Stress ، Nuclear factor erythroid ۲-related factor ۲.