Expression of P۶۳, P۱۶ and CK۱۷ in Atypical Squamous Metaplasia and Cervical Intraepithelial Neoplasia

Background & Objective: Cervical intraepithelial neoplasia (CIN) is a dysmaturation process in squamous cells in epithelial layer, which highly increases the risk of developing cervical cancer. The aim of this study was to compare the expression of three biomarkers, p۱۶, p۶۳, and CK۱۷ in patients with CIN and in those with atypical squamous metaplasia (ASM). Methods: In this study, ۱۰۰ patients underwent a colposcopy-guided cervix biopsy. Immunostaining for the biomarkers was undertaken on tissue samples containing ASM (n=۵۰) and CIN (n=۵۰). Results: Immunostaining for CK۷, P۶۳, and P۱۶ in patients with CIN significantly increased compared to ASM subjects. Conclusion: The expression of CK۱۷, P۶۳, and P۱۶ in CIN varied from that in ASM. The mentioned biomarkers were reliable factors to distinguish ASM from CIN; however, all biomarkers could differentiate CIN from its mimics due to their high degree of sensitivity and specificity.

کلیدواژه ها:

Cervical Intraepithelial Neoplasia ، P۶۳ ، P۱۶ ، CK۱۷