Concerning the Prevalence of HPV Genotypes and the Evaluation of Pap smear Results in Iranian Population: An Update

Human papillomavirus infection is one of the most common genital infections. More than ۱۰۰ types of the virus have been identified, most of which can infect the genital mucosa. The virus is associated with cancerous and precancerous lesions of the cervix. Some types, such as human papillomavirus ۱۶ and ۱۸, are highly carcinogenic; some other types, such as human papillomavirus ۶ and ۱۱, are mildly carcinogenic, with HPV ۳۱.۳۳ in between. This study describes the relationship between different types of HPV infection and the findings of a Pap smear. In this prospective study, ۱,۵۰۰ samples from patients who admitted to a private Pathology Laboratory in Isfahan were collected during the years ۲۰۱۹-۲۰۲۰. Two samples were collected from each patient, one for Pap smear study and the other for polymerase chain reaction (PCR) test to detect different types of human papillomavirus (HPV) infection. In a study of ۱,۵۰۰ samples, ۲۳۶ were positive for Papillomavirus (HPV) infection in Pap smear. By examining the genotype of positive examples, it was found that ۱۴.۸% of the samples were infected with type ۱۶, and ۱.۷% were infected with type ۸۲. HPV infection is common in Iran and is almost similar to European countries such as Germany and Spain. We also found that using a polymerase chain reaction (PCR) method to detect HPV viruses in vaginal secretions could be very useful. Our findings also show which disease is most associated with each type of HPV.

کلیدواژه ها:

HPV Serotypes ، Pap smear ، Papillomavirus